Delayed administration of recombinant plasma gelsolin improves survival in a murine model of severe influenza.
Yang Z1, Bedugnis A1, Levinson S2, DiNubile M2, Stossel T2, Lu Q1, Kobzik L1.November 6, 2019 Abstract Background: Host-derived inflammatory responses contribute to the morbidity and mortality of severe influenza, suggesting that immunomodulatory therapy may improve outcomes. The normally circulating protein, human plasma gelsolin, is available in recombinant form (rhu-pGSN) and has beneficial effects in a variety of pre-clinical models of inflammation […]