Publications of Interest

Over 400 scientific publications have been written about plasma gelsolin. We’ve selected publications relevant to our research and our technology platform.

Plasma Gelsolin Levels are Associated with Diabetes, Sex, Race, and Poverty

Hooten, Nicole Noren, et al. Journal of Translational Medicine, 10 Mar 2023

Blood-Borne Microparticles are an Inflammatory Stimulus in Type 2 Diabetes Mellitus

Thom, SR, et al. ImmunoHorizons, 1 Jan 2023

Adjunctive Recombinant Human Plasma Gelsolin for Severe Coronavirus Disease 2019 Pneumonia

DiNubile, Mark J, et al. Open Forum Infectious Dieases, 25 July 2022.

Quorum Sensing by Gelsolin Regulates Programmed Cell Death 4 Expression and a Density-Dependent Phenotype in Macrophages

Reshma Kumari Sharma, et al. Journal of Immunology, 06 August 2021.

Plasma gelsolin modulates the production and fate of IL-1β-containing microparticles following high-pressure exposure and decompression

Bhopale, Veena M., et al. Journal of Applied Physiology, 25 March 2021.

An immune-based biomarker signature is associated with mortality in COVID-19 patients

Abers, Michael S., et al. JCI Insight, 24 November 2020.

Recombinant Human Plasma Gelsolin Improves Survival and Attenuates Lung Injury in a Murine Model of Multidrug-Resistant Pseudomonas Aeruginosa Pneumonia.

DiNubile, Mark J, et al. Open Forum Infectious Disease,  19 June 2020.

Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection

Messner, Christoph B., et al. Cell Systems, Cell Press, 2 June 2020. 

Recombinant Human Plasma Gelsolin Stimulates Phagocytosis while Diminishing Excessive Inflammatory Responses in Mice with Pseudomonas aeruginosa Sepsis

Piktel, E., et al. Int. J. Mol. Sci., 4 April 2020

Large-Scale Multi-Omic Analysis of COVID-19 Severity.

Overmyer, Katherine A, et al. MedRxiv, Cold Spring Harbor Laboratory Press, 1 Jan. 2020.

Delayed Administration of Recombinant Plasma Gelsolin Improves Survival in a Murine Model of Severe Influenza.

Yang, Zhiping, et al.  F1000Research, F1000 Research Limited, 6 Nov. 2019.

Delayed Administration of Recombinant Plasma Gelsolin Improves Survival in a Murine Model of Penicillin-Susceptible and Penicillin-Resistant Pneumococcal Pneumonia.

Yang, Zhiping, et al. The Journal of Infectious Diseases, Oxford University Press, 26 Sept. 2019.

Low Admission Plasma Gelsolin Concentrations Identify Community-Acquired Pneumonia Patients at High Risk for Severe Outcomes.

Self, Wesley H, et al.  Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, Oxford University Press, 13 Sept. 2019.

Plasma Gelsolin: Indicator of Inflammation and Its Potential as a Diagnostic Tool and Therapeutic Target

Piktel, Ewelina, et al.  International Journal of Molecular Sciences, 25 August 2018

Free Actin Impairs Macrophage Bacterial Defenses via Scavenger Receptor MARCO Interaction with Reversal by Plasma Gelsolin.

Ordija, Christine M, et al.  American Journal of Physiology. Lung Cellular and Molecular Physiology, American Physiological Society, 1 June 2017.

Community-Acquired Pneumonia Requiring Hospitalization Among U.S. Adults.

Jain, Seema, et al.  The New England Journal of Medicine, U.S. National Library of Medicine, 30 July 2015.

Plasma Gelsolin Improves Lung Host Defense Against Pneumonia by Enhancing Macrophage NOS3 Function.

Yang, Zhiping, et al.  American Journal of Physiology. Lung Cellular and Molecular Physiology, American Physiological Society, 1 July 2015.

The Value of Decreased Plasma Gelsolin Levels in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis in Diagnosis and Disease Activity Evaluation.

Li, H, et al. SAGE Journals., 11 October 2013.

Reduction of Plasma Gelsolin Levels Correlates with Development of Multiple Organ Dysfunction Syndrome and Fatal Outcome in Burn Patients

Li-feng Huang, Yong-ming Yao, et al.  PLOS ONE, Public Library of Science. 1 November, 2011

Plasma Gelsolin and Circulating Actin Correlate with Hemodialysis Mortality.

Lee, Po-Shun, et al.  Journal of the American Society of Nephrology : JASN, American Society of Nephrology, May 2009.

Decreased Levels of the Gelsolin Plasma Isoform in Patients with Rheumatoid Arthritis.

Osborn, Teresia M, et al. Arthritis Research & Therapy, BioMed Central, 2008.

Extracellular Gelsolin Binds Lipoteichoic Acid and Modulates Cellular Response to Proinflammatory Bacterial Wall Components.

Bucki, Robert, et al. Journal of Immunology (Baltimore, Md. : 1950), U.S. National Library of Medicine, 1 Oct. 2008.

Modifications of Cellular Responses to Lysophosphatidic Acid and Platelet-Activating Factor by Plasma Gelsolin.

Osborn, Teresia M, et al.  American Journal of Physiology. Cell Physiology, U.S. National Library of Medicine, Apr. 2007.

Plasma Gelsolin is a Marker and Therapeutic Agent in Animal Sepsis.

Lee, Po-Shun, et al. Critical Care Medicine, U.S. National Library of Medicine, Mar. 2007.

Relationship of Plasma Gelsolin Levels to Outcomes in Critically Ill Surgical Patients

Lee, Po-Shun, et al.  Annals of Surgery, U.S. National Library of Medicine, Mar. 2006.

Recombinant Plasma Gelsolin Infusion Attenuates Burn-Induced Pulmonary Microvascular Dysfunction.

Rothenbach, Patricia A., et al.  Journal of Applied Physiology, 1 Jan. 2004.

Recombinant Plasma Gelsolin Diminishes the Acute Inflammatory Response to Hyperoxia in Mice.

Christofidou-Solomidou, Melpo, et al. Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research, U.S. National Library of Medicine, Jan. 2002.