We have expanded our COVID-19 treatment phase 2 clinical trial footprint within the EU.-

Publications of Interest

Over 400 scientific publications have been written about plasma gelsolin. We’ve selected publications relevant to our research and our technology platform.

Recombinant Human Plasma Gelsolin Improves Survival and Attenuates Lung Injury in a Murine Model of Multidrug-Resistant Pseudomonas Aeruginosa Pneumonia.

DiNubile, Mark J, et al. OUP Academic, Oxford University Press, 19 June 2020.

Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection

Messner, Christoph B., et al. Cell Systems, Cell Press, 2 June 2020. 

Large-Scale Multi-Omic Analysis of COVID-19 Severity.

Overmyer, Katherine A, et al. MedRxiv, Cold Spring Harbor Laboratory Press, 1 Jan. 2020.

Low Admission Plasma Gelsolin Concentrations Identify Community-Acquired Pneumonia Patients at High Risk for Severe Outcomes.

Self, Wesley H, et al.  Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, Oxford University Press, 13 Sept. 2019.

Community-Acquired Pneumonia Requiring Hospitalization Among U.S. Adults.

Jain, Seema, et al.  The New England Journal of Medicine, U.S. National Library of Medicine, 30 July 2015.

Delayed Administration of Recombinant Plasma Gelsolin Improves Survival in a Murine Model of Severe Influenza.

Yang, Zhiping, et al.  F1000Research, F1000 Research Limited, 6 Nov. 2019.

Delayed Administration of Recombinant Plasma Gelsolin Improves Survival in a Murine Model of Penicillin-Susceptible and Penicillin-Resistant Pneumococcal Pneumonia.

Yang, Zhiping, et al. The Journal of Infectious Diseases, Oxford University Press, 26 Sept. 2019.

Free Actin Impairs Macrophage Bacterial Defenses via Scavenger Receptor MARCO Interaction with Reversal by Plasma Gelsolin.

Ordija, Christine M, et al.  American Journal of Physiology. Lung Cellular and Molecular Physiology, American Physiological Society, 1 June 2017.

Plasma Gelsolin Improves Lung Host Defense Against Pneumonia by Enhancing Macrophage NOS3 Function.

Yang, Zhiping, et al.  American Journal of Physiology. Lung Cellular and Molecular Physiology, American Physiological Society, 1 July 2015.

Reduction of Plasma Gelsolin Levels Correlates with Development of Multiple Organ Dysfunction Syndrome and Fatal Outcome in Burn Patients

Li-feng Huang, Yong-ming Yao, et al.  PLOS ONE, Public Library of Science.

Recombinant Plasma Gelsolin Infusion Attenuates Burn-Induced Pulmonary Microvascular Dysfunction.

Rothenbach, Patricia A., et al.  Journal of Applied Physiology, 1 Jan. 2004.

Recombinant Plasma Gelsolin Diminishes the Acute Inflammatory Response to Hyperoxia in Mice.

Christofidou-Solomidou, Melpo, et al. Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research, U.S. National Library of Medicine, Jan. 2002.

The Value of Decreased Plasma Gelsolin Levels in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis in Diagnosis and Disease Activity Evaluation.

Li, H, et al. SAGE Journals.

Modifications of Cellular Responses to Lysophosphatidic Acid and Platelet-Activating Factor by Plasma Gelsolin.

Osborn, Teresia M, et al.  American Journal of Physiology. Cell Physiology, U.S. National Library of Medicine, Apr. 2007.

Plasma Gelsolin and Circulating Actin Correlate with Hemodialysis Mortality.

Lee, Po-Shun, et al.  Journal of the American Society of Nephrology : JASN, American Society of Nephrology, May 2009.

Relationship of Plasma Gelsolin Levels to Outcomes in Critically Ill Surgical Patients

Lee, Po-Shun, et al.  Annals of Surgery, U.S. National Library of Medicine, Mar. 2006.

Decreased Levels of the Gelsolin Plasma Isoform in Patients with Rheumatoid Arthritis.

Osborn, Teresia M, et al. Arthritis Research & Therapy, BioMed Central, 2008.

Plasma Gelsolin is a Marker and Therapeutic Agent in Animal Sepsis.

Lee, Po-Shun, et al. Critical Care Medicine, U.S. National Library of Medicine, Mar. 2007.

Extracellular Gelsolin Binds Lipoteichoic Acid and Modulates Cellular Response to Proinflammatory Bacterial Wall Components.

Bucki, Robert, et al. Journal of Immunology (Baltimore, Md. : 1950), U.S. National Library of Medicine, 1 Oct. 2008.