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February, 2020: BioAegis Commentary Featured on CNBC

Commentary Steve Cordovano, co-founder of BioAegis Therapeutics Published February 25, 2020 On Tuesday the number of confirmed coronavirus cases worldwide hit 80,370, with more than 2,700 deaths worldwide, raising concerns that the outbreak has reached a new stage and could continue its global spread. But why is it that the health sector is so woefully unprepared …

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Low Admission Plasma Gelsolin Concentrations Identify Community-acquired Pneumonia Patients at High Risk for Severe Outcomes.

Self WH1, Wunderink RG2, DiNubile MJ3, Stossel TP3, Levinson SL3, Williams DJ4, Anderson EJ5, Bramley AM6, Jain S6, Edwards KM4, Grijalva CG7.September 13, 2019 Abstract BACKGROUND: Plasma gelsolin (pGSN) is an abundant circulating protein that neutralizes actin exposed by damaged cells, modulates inflammatory responses, and enhances alveolar macrophage antimicrobial activity. We investigated whether adults with low pGSN at hospital admission for community-acquired pneumonia (CAP) were …

Low Admission Plasma Gelsolin Concentrations Identify Community-acquired Pneumonia Patients at High Risk for Severe Outcomes. Read More »

Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults.

Jain S1, Self WH, Wunderink RG, Fakhran S, Balk R, Bramley AM, Reed C, Grijalva CG, Anderson EJ, Courtney DM, Chappell JD, Qi C, Hart EM, Carroll F, Trabue C, Donnelly HK, Williams DJ, Zhu Y, Arnold SR, Ampofo K, Waterer GW, Levine M, Lindstrom S, Winchell JM, Katz JM, Erdman D, Schneider E, Hicks LA, McCullers JA, Pavia AT, Edwards KM, Finelli L; CDC EPIC Study Team. Abstract BACKGROUND: Community-acquired pneumonia is a leading infectious cause of hospitalization and death among U.S. adults. Incidence estimates of …

Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults. Read More »

Delayed administration of recombinant plasma gelsolin improves survival in a murine model of severe influenza.

Yang Z1, Bedugnis A1, Levinson S2, DiNubile M2, Stossel T2, Lu Q1, Kobzik L1.November 6, 2019 Abstract Background: Host-derived inflammatory responses contribute to the morbidity and mortality of severe influenza, suggesting that immunomodulatory therapy may improve outcomes. The normally circulating protein, human plasma gelsolin, is available in recombinant form (rhu-pGSN) and has beneficial effects in a variety of pre-clinical models of inflammation …

Delayed administration of recombinant plasma gelsolin improves survival in a murine model of severe influenza. Read More »

Delayed Administration of Recombinant Plasma Gelsolin Improves Survival in a Murine Model of Penicillin-Susceptible and Penicillin-Resistant Pneumococcal Pneumonia.

Yang Z1, Bedugnis A1, Levinson S2, Dinubile M2, Stossel T2, Lu Q1, Kobzik L1.September 26, 2019 Abstract Therapy to enhance host immune defenses may improve outcomes in serious infections, especially for antibiotic-resistant pathogens. Recombinant human plasma gelsolin (rhu-pGSN), a normally circulating protein, has beneficial effects in diverse preclinical models of inflammation and injury. We evaluated delayed therapy (24-48 hours after challenge) …

Delayed Administration of Recombinant Plasma Gelsolin Improves Survival in a Murine Model of Penicillin-Susceptible and Penicillin-Resistant Pneumococcal Pneumonia. Read More »

Free actin impairs macrophage bacterial defenses via scavenger receptor MARCO interaction with reversal by plasma gelsolin.

Ordija CM1, Chiou TT1,2, Yang Z1, Deloid GM1, de Oliveira Valdo M1, Wang Z1, Bedugnis A1, Noah TL3, Jones S4, Koziel H5, Kobzik L6.June 1, 2017 Abstract Lung injury can release intracellular actin into the alveolar milieu and is also associated with increased susceptibility to secondary infections. We investigated the effect of free (extracellular) actin on lung macrophage host defense functions. Western blot analysis demonstrated …

Free actin impairs macrophage bacterial defenses via scavenger receptor MARCO interaction with reversal by plasma gelsolin. Read More »

Plasma gelsolin improves lung host defense against pneumonia by enhancing macrophage NOS3 function

Yang Z1, Chiou TT2, Stossel TP3, Kobzik L4.June 1, 2017 Abstract Plasma gelsolin (pGSN) functions as part of the “extracellular actin-scavenging system,” but its potential to improve host defense against infection has not been studied. In a mouse model of primary pneumococcal pneumonia, recombinant human pGSN (rhu-pGSN) caused enhanced bacterial clearance, reduced acute inflammation, and improved survival. In …

Plasma gelsolin improves lung host defense against pneumonia by enhancing macrophage NOS3 function Read More »

Reduction of Plasma Gelsolin Levels Correlates with Development of Multiple Organ Dysfunction Syndrome and Fatal Outcome in Burn Patients

Li-feng Huang, Yong-ming Yao, Jin-feng Li, Ning Dong, Chen Liu,Yan Yu, Li-xin He, Zhi-yong ShengNovember 1, 2011 Abstract Background Depletion of the circulating actin-binding protein, plasma gelsolin (pGSN) has been described in critically ill surgical patients. We hypothesized that the extent of pGSN reduction might correlate with different outcome of burn patients. The study was …

Reduction of Plasma Gelsolin Levels Correlates with Development of Multiple Organ Dysfunction Syndrome and Fatal Outcome in Burn Patients Read More »

Recombinant plasma gelsolin infusion attenuates burn-induced pulmonary microvascular dysfunction.

Patricia A. Rothenbach, Benny Dahl, Jason J. Schwartz, Grant E. O’Keefe, Masaya Yamamoto, William M. Lee, Jureta W. Horton, Helen L. Yin, and Richard H. TurnageJanuary 1, 2004 Abstract Reduced plasma concentrations of the extracellular actin-binding proteins gelsolin and Gc-globulin correlate with pulmonary failure and death in humans after injury. The purpose of this study was to investigate the role of plasma gelsolin …

Recombinant plasma gelsolin infusion attenuates burn-induced pulmonary microvascular dysfunction. Read More »

Recombinant plasma gelsolin diminishes the acute inflammatory response to hyperoxia in mice.

Christofidou-Solomidou M1, Scherpereel A, Solomides CC, Christie JD, Stossel TP, Goelz S, DiNubile MJ.January, 2002 Abstract BACKGROUND: The acute respiratory distress syndrome remains a common and poorly understood complication of a variety of insults. Ventilation with high concentrations of inspired oxygen may further damage already compromised lungs. By scavenging extracellular actin and modulating the effects of lysophosphatidic acid, plasma gelsolin could …

Recombinant plasma gelsolin diminishes the acute inflammatory response to hyperoxia in mice. Read More »