Publication

Patricia A. Rothenbach, Benny Dahl, Jason J. Schwartz, Grant E. O’Keefe, Masaya Yamamoto, William M. Lee, Jureta W. Horton, Helen L. Yin, and Richard H. TurnageJanuary 1, 2004 Abstract Reduced plasma concentrations of the extracellular actin-binding proteins gelsolin and Gc-globulin correlate with pulmonary failure and death in humans after injury. The purpose of this study was to investigate the role of plasma gelsolin …

Recombinant plasma gelsolin infusion attenuates burn-induced pulmonary microvascular dysfunction. Read More »

Christofidou-Solomidou M1, Scherpereel A, Solomides CC, Christie JD, Stossel TP, Goelz S, DiNubile MJ.January, 2002 Abstract BACKGROUND: The acute respiratory distress syndrome remains a common and poorly understood complication of a variety of insults. Ventilation with high concentrations of inspired oxygen may further damage already compromised lungs. By scavenging extracellular actin and modulating the effects of lysophosphatidic acid, plasma gelsolin could …

Recombinant plasma gelsolin diminishes the acute inflammatory response to hyperoxia in mice. Read More »

YL Hu*, H Li*, WH Li, HX Meng, YZ Fan, WJ Li, YT Ji, H Zhao, L Zhang, XM Jin, FM ZhangFM ZhangOctober 11, 2013 Abstract Plasma gelsolin, the extracellular gelsolin isoform, circulates in the blood of healthy individuals at a concentration of 200 ± 50 mg/l and plays important roles in the extracellular actin-scavenging system during tissue damage. Decreased plasma gelsolin levels have been observed in many …

The value of decreased plasma gelsolin levels in patients with systemic lupus erythematosus and rheumatoid arthritis in diagnosis and disease activity evaluation Read More »

Osborn TM1, Dahlgren C, Hartwig JH, Stossel TP.April, 2007 Abstract Gelsolin is a highly conserved intracellular actin-binding protein with an extracellular isoform, plasma gelsolin (pGSN). Blood concentrations of pGSN decrease in response to diverse tissue injuries. Depletion of pGSN to critical levels precedes and often predicts complications of injuries such as lung permeability changes and death. Administration of …

Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin. Read More »

Lee PS1, Sampath K, Karumanchi SA, Tamez H, Bhan I, Isakova T, Gutierrez OM, Wolf M, Chang Y, Stossel TP, Thadhani R.May, 2009 Abstract Plasma gelsolin (pGSN) binds actin and bioactive mediators to localize inflammation. Low pGSN correlates with adverse outcomes in acute injury, whereas administration of recombinant pGSN reduces mortality in experimental sepsis. We found that mean pGSN levels of 150 patients randomly selected …

Plasma gelsolin and circulating actin correlate with hemodialysis mortality. Read More »

Lee PS1, Drager LR, StosselTP, Moore FD, Rogers SO.March, 2006 Abstract OBJECTIVE:To examine the relationship between plasma gelsolin levels and mortality following surgery or trauma.BACKGROUND:Few simple predictive diagnostic tests are available to predict mortality following surgery or trauma. We hypothesize that plasma concentrations of gelsolin, a protein that responds to injured tissue, might be a predictor of patient outcomes.METHODS:We …

Relationship of plasma gelsolin levels to outcomes in critically ill surgical patients. Read More »

Osborn TM1, Verdrengh M, Stossel TP, Tarkowski A, Bokarewa M.September, 2008 Abstract INTRODUCTION: Gelsolin is an intracellular actin-binding protein involved in cell shape changes, cell motility, and apoptosis. An extracellular gelsolin isoform, plasma gelsolin circulates in the blood of healthy individuals at a concentration of 200 +/- 50 mg/L and has been suggested to be a key component of …

Decreased levels of the gelsolin plasma isoform in patients with rheumatoid arthritis. Read More »

Plasma gelsolin is a marker and therapeutic agent in animal sepsis. Lee PS1, Waxman AB, Cotich KL, Chung SW, Perrella MA, Stossel TP. Abstract OBJECTIVE: Plasma gelsolin is a circulating actin-binding protein that serves a protective role against tissue injuries. Depletion of plasma gelsolin in systemic inflammation may contribute to adverse outcomes. We examined the role of plasma gelsolin in …

Plasma gelsolin is a marker and therapeutic agent in animal sepsis. Read More »

Bucki R1, Byfield FJ, Kulakowska A, McCormick ME, Drozdowski W, Namiot Z, Hartung T, Janmey PA.October 1, 2008 Abstract The various functions of gelsolin in extracellular compartments are not yet clearly defined but include actin scavenging and antiinflammatory effects. Gelsolin was recently reported to bind endotoxin (LPS) from various Gram-negative bacteria with high affinity. In this study we investigate whether gelsolin also …

Extracellular gelsolin binds lipoteichoic acid and modulates cellular response to proinflammatory bacterial wall components. Read More »